The Design Pattern Framework 4.5 uses many of the new features available in VS 2012 and .NET 4.5.
Examples include LocalDb, SimpleMembership, Web API, async / await keywords, and others.
So the short answer is no, the latest version is not compatible with VS 2010.
However, your purchase includes all prior versions. Here is a list
Of course, it does not have all the latest and greatest features that 4.5 has.
Hope this answers your question..
Jack Poorte, Aug 03, 2013