VS 2010 and Design Pattern Framework 4.5

Hello Lyle: 

The Design Pattern Framework 4.5 uses many of the new features available in VS 2012 and .NET 4.5.
Examples include LocalDb, SimpleMembership, Web API, async / await keywords, and others. 

So the short answer is no, the latest version is not compatible with VS 2010.

However, your purchase includes all prior versions. Here is a list

• Design Pattern Framework 4.0 for VS 2010 / .NET 4.0
• Design Pattern Framework 3.5 for VS 2008 / .NET 3.5
• Design Pattern Framework 2.0 for VS 2005 / .NET 2.0
• Design Pattern Framework 1.1 for VS 2003 / .NET 1.1

So, with VS 2010 you can use the Design Pattern Framework 4.0. 
Of course, it does not have all the latest and greatest features that 4.5 has. 

Hope this answers your question..
Jack